Journal article
Does use of anal cytology as a triage test improve the performance of high-risk human papillomavirus screening in gay and bisexual men for anal cancer prevention?
F Jin, IM Poynten, RJ Hillman, C Law, M Molano, CK Fairley, SM Garland, DJ Templeton, AE Grulich, J Roberts, B Acraman, A Carr, S Carroll, D Cooper, A Cornall, L Crampton, A Farnsworth, L Feeney, E Fraissard, R Hillman Show all
International Journal of Cancer | WILEY | Published : 2025
DOI: 10.1002/ijc.35185
Abstract
Anal high-risk human papillomavirus (HRHPV) testing-based anal cancer screening gay and bisexual men (GBM) is associated with high sensitivity, but low specificity. We report the potential role of triage use of anal cytology with HRHPV testing in detecting 12-month persistent anal high-grade squamous epithelial lesions (HSIL) in a cohort of GBM in Sydney, Australia. Participants were GBM from the Study of the Prevention of Anal Cancer (SPANC) who underwent annual anal HPV testing, cytology, and high-resolution anoscopy (HRA)-guided histology. The sensitivity and specificity of five screening algorithms based on HRHPV test results with triage use of anal cytology (atypical squamous cells of u..
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Awarded by University of New South Wales
Funding Acknowledgements
The authors thank all the participants, histopathologist Dr Clare Biro, and cytologists Deborah Ekman, Ross McDonald, Marjorie Adams, Alison Barnett, and Joanne Crescini for their scientific expertise. The SPANC study team includes Brian Acraman, Andrew Carr, Susan Carroll, David Cooper, Alyssa Cornall, Leonie Crampton, Christopher Fairley, Annabelle Farnsworth, Lance Feeney, Eddie Fraissard, Suzanne Garland, Andrew Grulich, Richard Hillman, Kirsten Howard, Fengyi Jin, Carmella Law, Matthew Law, Dorothy Machalek, Kirsten McCaffery, Patrick McGrath, Robert Mellor, Richard Norris, Matthew O'Dwyer, Susan Pendlebury, Kathy Petoumenos, Samuel Phillips, Monica Molano, I Mary Poynten, Garrett Prestage, Adele Richards, Jennifer Roberts, Lance Schema, Daniel Seeds, Eva Segelov, Sepehr Tabrizi, Dave Templeton, Julia Thurloe, Winnie Tong, and Rick Varma. Open access publishing facilitated by University of New South Wales, as part of the Wiley - University of New South Wales agreement via the Council of Australian University Librarians.